Publications

2024

Saucedo, A., Subbarao, M., Jemal, M., Mesa-Diaz N. L., Smith, J. L., Vernaza, A., Du, L., and Kerwin. S. M.. Flow and On-Water Synthesis and Cancer Cell Cytotoxicity of Caffeic Acid Phenethyl Amide (CAPA) Derivatives. Int. J. Mol. Sci. 2024; 25: 8051.

 Cardus, D.F., Smith, M.T., Vernaza, A., Smith, J. L., Del Buono, B., Parajuli, A., Lewis, E.G., Mesa-Diaz, N., Du, L. (2024) Systematic Analysis of miR-506-3p Target Genes Identified Key Mediators of Its Differentiation-Inducing Function. Genes. 2024;15(10): 1268.

Aksenov, D. A., Smith J. L., Aksenov, A. V., Prityko, L. A., Aksenov, N. A., Kuzminov, I. K., Aleksandrova, E. V., Sathish, P., Mesa-Diaz, N., Vernaza, A., Zhang, A., Du, L., Kornienko, A. 2-(3-Indolyl)acetamides and their oxazoline analogues: Anticancer SAR study. (2024) Bioorg. Med. Chem. Lett. 102, 129681.  DOI: 10.1016/j.bmcl.2024.129681

Vernaza, A., Cardus, D. F., Smith, J. L., Partridge, V., Baker, A. L., Lewis, E. G., Zhang, A., Zhao, Z., Du, L. Identification of CDKN3 as a Key Gene that Regulates Neuroblastoma Cell Differentiation.  (2024) Journal of Cancer, 15(5), 1153–1168. DOI: 10.7150/jca.89660

2023

Mesa-Diaz, N., Smith, M.T., Cardus, D.F., Du, L. (2023) Development of Shortened miR-506-3p Mimics Exhibiting Strong Differentiation-Inducing Activity in Neuroblastoma Cells. Molecules, 28(17), 6295. doi: 10.3390/molecules28176295.

Johns, A.C., Oviedo. A., Zhao. Z., Du. L., Kornienko, A. Discovery of 5-sulfonyltetrazoles as neuroblastoma differentiation agents. (2023). Bioorg Med Chem Lett, 94, 129455. doi: 10.1016/j.bmcl.2023.129455.

2022

Stollmaier, J. G., Thomson, J., Endoma-Arias, M A., Simionescu, R., Vernaza, A., Mesa-Diaz, N., Smith, M.T., Du, L., Kornienko, A., Hudlicky, T. (2022). Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine. Molecules, 27, 4141.  https://doi.org/10.3390/molecules27134141.

Habaz, L., Korey Bedard, K., Smith, M.T, Du, L., Kornienko, A., Hudlicky, T. (2022). Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity. Molecules, 27, 3809.  https://doi.org/10.3390/molecules27123809

Schwartz, Z. T., Theisen, P. D., Bjornstal, O. T., Rodebaugh, M., Jemal, M. A., Lee, D., Shelton, S. D., Zhao, Z., Du, L., Sean M. Kerwin, S. M.  (2022). Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues. Molecules, 27, 1792. https://doi.org/10.3390/molecules27061792

Baker, A. L., Du, L. (2022). The function and regulation of SAPCD2 in physiological and oncogenic processes. J Cancer, 13(7), 2374-2387. Review.

2021

Aksenov, A. V., Arutiunov, N. A., Kirilov, N. K., Aksenov, D. A., Grishin, I. Y., Aksenov, N. A., Wang, H., Du, L., Betancourt, T., Pelly, S., Kornienko, A., Rubin, M. (2021). [3+2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor. Organic & Biomolecular Chemistry, 19, 7234.

Ticli, V., Zhao, Z., Du, L., Kornienko, A. V., & Hudlicky, T. (2021). Synthesis and biological evaluation of 10-benzyloxy-Narciclasine. Tetrahedron, 101, 132505.

Zhao, G., Du, L., Zhang, L., & Jia, Y. (2021). LIM domain only 1: an oncogenic transcription cofactor contributing to the tumorigenesis of multiple cancer types. Chinese Medicine Journal, 134(9), 1017–1030. https://doi.org/10.1097/CM9.0000000000001487

Rastogi, S. K., Dunnigan, J. K., Towne, A. C., Zhao, Z., Du, L., & Brittain, W. J. (2021). Photopharmacology of Azo-Combretastatin-A4: Utilizing Tubulin Polymerization Inhibitors and Green Chemistry as the Key Steps. Current Organic Chemistry, 25, 2457.  https://doi.org/10.2174/1385272825666210526151222

Rastogi, S. K., Zhao, Z., Gildner, M. B. C., Shoulders, B. A., Velasquez, T. L., Blumenthal, M. O., Du, L., Brittain, W. J. (2021). Synthesis, optical properties and in vitro cell viability of novel spiropyrans and their photostationary states. Tetrahedron, 80, 131854.

2020
  • Aksenov, N. A., Aksenov, A. V., Kirilov, N. K., Arutiunov, N. A., Aksenov, D. A., Maslivetc, V., … Kornienko, A. V. (2020). Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity. Organic & Biomolecular Chemistry, 18(34), 6651–6664. https://doi.org/https://doi.org/10.1039/D0OB01007C
  • Eyong, K. O., Ketsemen, H. L., Zhao, Z., Du, L., Ingels, A., Mathieu, V., … Romo, D. (2020). Anti-proliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines. Medicinal Chemistry Research, 29, 1058–1066.
  • Baker, A. L., Zhao, Z., & Du, L. (2020). Investigation of the Oncogenic Role of the Cell Cycle Regulator SAPCD2 in Pediatric Neuroblastoma. FASEB Journal, 34(No.1 Suppl). Retrieved from https://www.fasebj.org/doi/abs/10.1096/fasebj.2019.33.1_supplement.634.5
  • Zhao, Z., Shelton, S. D., Oviedo, A., Baker, A. L., Bryant, C. P., Omidvarnia, S., & Du, L. (2020). The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression. Journal of Experimental and Clinical Cancer Research, 39(1), 41. https://doi.org/10.1186/s13046-020-1531-2.
2019
  • Kosti, A., Du, L., Shivram, H., Qiao, M., Burns, S., Garcia, J. G., … Penalva LOF. (2019). The ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State. Molecular Cancer Research : MCR, 18(1), 68–78. https://doi.org/10.1158/1541-7786.MCR-19-0187
  • Aksenov, A. V., Aksenov, D. A., Arutiunov, N. A., Aksenov, N. A., Aleksandrova, E. V., Zhao, Z., … Rubin, M. (2019). Synthesis of Spiro[indole-3,5’-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles. The Journal of Organic Chemistry, 84(11), 7123–7137. https://doi.org/10.1021/acs.joc.9b00808
  • Jemal, M. A., Schwartz, Z. T., Zhao, Z., Du, L., Du, L., Du, L. D., … Du, L. M. (2019). Overcoming the Rapid Metabolism of the Promising Anticancer Natural Product Rooperol. FASEB Journal, 33(No.1 Suppl). Retrieved from https://www.fasebj.org/doi/abs/10.1096/fasebj.2019.33.1_supplement.634.5
2018
  • Rastogi, S. K., Zhao, Z., Barrett, S. L., Shelton, S. D., Zafferani, M., Anderson, H. E., … Brittain, W. J. (2018). Photoresponsive azo-combretastatin A-4 analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 143, 1–7. https://doi.org/10.1016/j.ejmech.2017.11.012
  • Zhao, Z., Partridge, V., Sousares, M., Shelton, S., Holland, C., Pertsemlidis, A., & Du, L. (2018). microRNA-2110 functions as a tumor suppressor in neuroblastoma by directly targeting Tsukushi. PLos One, 13(12), e0208777.
  • Du, L., Zhao, Z., Milind, S., Shelton, S. S., Tzu-Hung, H., Ma, X., … Pertsemlidis, A. (2018). LMO1 functions an oncogene through regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget, 9, 29601–29618.
  • Shelton, S. D., Zhao, Z., & Du, L. (2018). RXRA is a direct target gene of miR-506-3p that regulates oncogene MYCN expression and cell differentiation in neuroblastoma. FASEB Journal, 32(No.1 Suppl). Retrieved from www.fasebj.org/content/32/1_Supplement/804.16
  • Medrano, G., Zhao, Z., & Du, L. (2018). The Role of the Vacuolar (H+)-ATPase in Neuroblastoma Cell Differentiation induced by microRNA 506-3p. FASEB Journal, 32(No.1 Suppl). Retrieved from www.fasebj.org/content/32/1_Supplement/804.3
  • Yu, X., Zhang, Y., Cavazos, D., Ma, X., Zhao, Z., Du, L., & Pertsemlidis, A. (2018). miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Cell Death and Disease, 9(2), 193.
2017
  • Sousares, M., Partridge, V., Weigum, S., & Du, L. (2017). MicroRNAs in neuroblastoma differentiation and differentiation therapy. Advances in Modern Oncology Research, 3(5), 213. https://doi.org/10.18282/amor.v3.i5.233
  • Li, L.-Y., Ma, R.-L., Du, L., & Wu, A.-S. (2017). Ozonated autohemotherapy modulates the serum levels of inflammatory cytokines in gouty Patients. Journal of Open Access Rheumatology: Research and Reviews.
  • Partridge, V., Sousares, M., Zhao, Z., & Du, L. (2017). Current understanding on the role of cell cycle regulators in neuroblastoma. Med One, 2, e170010. https://doi.org/10.20900/mo.20170010
  • Zhang, Y., Ma, X., Yu, X., Patolia, H., Zhao, Z., Du, L., & Pertsemilidis, A. (2017). ncRNA regulation of eribulin response in neuroblastoma. Cancer Research, 77(13 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/77/13_Supplement/3506
  • Yu, X., Ma, X., Zhang, Y., Zhao, Z., Du, L., & Pertsemilidis, A. (2017). Therapeutic potential of miR-195 in nonsmall cell lung cancer. Cancer Research, 77(13 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/77/13_Supplement/5444
  • Sousares, M., & Du, L. (2017). MicroRNA-506-3p as a Differentiation Agent for Neuroblastoma. FASEB Journal, 31(No.1 Suppl). Retrieved from www.fasebj.org/content/31/1_Supplement/757.18
  • Partridge, V., & Du, L. (2017). The Role of CDKN3 in Neuroblastoma Differentiation. FASEB Journal, 31(No.1  Suppl). Retrieved from http://www.fasebj.org/action/doSearch?AllField=The+Role+of+CDKN3+in+Neuroblastoma+Differentiation
2016
  • Zhao, Z., Ma, X., Shelton, S. D., Sung, D. C., Li, M., Hernandez, D., … Du, L. (2016). A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells. Oncotarget, 7(48), 79372–79387. https://doi.org/10.18632/oncotarget.12676
  • Yu, X., Zhao, Z., Ma, X., Du, L., & Pertsemilidis, A. (2016). miR-195 represses the tumorigenesis of non-small cell lung cancer and synergizes with microtubule targeting agents. Cancer Research, 76(14 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/76/14_Supplement/1063
  • Ma, X., Yu, X., Zhao, Z., Patolia, H., Du, L., & Pertsemilidis, A. (2016). Non-coding RNA regulation of eribulin response in neuroblastoma. Cancer Research, 76(14 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/76/14_Supplement/1940
2015
  • Zhao, Z., Ma, X., Sung, D., Li, M., Kosti, A., Lin, G., … Du, L. (2015). microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. RNA Biology, 12(5), 538–554.
  • Borkowski, R., Du, L., Zhao, Z., McMillan, E., Kosti, A., Yang, CR., … Pertsemlidis, A. (2015). Genetic Mutation of p53 and Suppression of the 3 miR-17-92 Cluster Are Synthetic Lethal in Non–Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling. Cancer Research, 75(4), 666–675. https://doi.org/10.1158/0008-5472
2014
  • Zhao, Z., Ma, X., Hsiao, TH., Lin, G., Kosti, A., Yu, X., … Du, L. (2014). A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation. Oncotarget, 5(9), 2499–2512.
  • Liqin Du, Zhao, Z., Ma, X., Hsiao, TH., Chen, Y., Young, E., … Pertsemlidis, A. (2014). miR-93-directed down-regulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene, 33, 4307–4315.
  • Zhao, Z., Ma, X., Yu, X., Minna, J. D., Pertsemilidis, A., & Du, L. (2014). LMO1 is a novel oncogene in neuroendocrine lung cancer. Cancer Research, 74(19 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/74/19_Supplement/466
  • Yu, X., Zhao, Z., Ma, X., Du, L., & Pertsemilidis, A. (2014). A high-throughput screen identifies microRNAs regulating lung cancer cell survival and response to paclitaxel. Cancer Research, 74(19 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/74/19_Supplement/3545
2013
  • Du, L., Borkowski, R., Zhao, Z., Yu, X., Ma, X., & Pertsemlidis, A. (2013). A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. RNA Biology, 10(11), 1700–1713.
  • DeSevo, C., Du, L., Behrens, C., Wistuba, I., Minna, J. D., & Pertsemilidis, A. (2013). miR-10a regulates PI3K signaling and paclitaxel response in NSCLC. Cancer Research, 73(8 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/73/8_Supplement/3049
  • Du, L., Zhao, Z., Young, E., Ma, X., Wistuba, I., & Pertsemilidis, A. (2013). miR-93-directed down-regulation of Dab2 defines a novel oncogenic pathway in lung cancer. Cancer Research, 73(8 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/73/8_Supplement/3096
2012
  • Du, L., Subauste, MC., DeSevo, C., Zhao, Z., Baker, M., Borkowski, R., … Pertsemlidis, A. (2012). miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS ONE, 7(6), e39167.
  • Du, L., & Pertsemlidis, A. (2012). microRNA regulation of cell viability and drug sensitivity in lung cancer. Exp Opin Biol Ther, 12(9), 1221–1239.
  • Du, L., DeSevo, C., Borkowski, R., Baker, M., Minna, J. D., & Pertsemilidis, A. (2012). microRNA regulation of cell viability and drug response in cancer. Cancer Research, 72(8 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/72/8_Supplement/140
  • DeSevo, C., Du, L., Behrens, C., Minna, J. D., & Pertsemilidis, A. (2012). miR-10a regulation of PIK3CA and response to taxol in non small cell lung cancer. Cancer Research, 72(2 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/72/2_Supplement/A2
  • Du, L., DeSevo, C., Borkoski, R., Baker, M., Minna, J. D., & Pertsemilidis, A. (2012). microRNA regulation of cell viability and drug sensitivity in lung cancer. Cancer Research, 72(2 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/72/2_Supplement/B7
2011
  • Nikolic, D., Calderon, L., Du, L., & Post, SR. (2011). SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation. BMC Immunol, 12, 37–46.
  • Subauste, MC., Ventura-Holman, Du, L., Sansoma, OJ., & Maher, JF. (2011). Fem1b antigen in the stool of Apc (Min) mice as a biomarker of early Wnt signaling activation in intestinal neoplasia. Cancer Epidemiol, 35(1), 97–100.
  • Du, L., & Pertsemlidis, A. (2011). Cancer and neurodegenerative disorders: pathogenic convergence through microRNA regulation. J Mol Cell Biol, 3(3), 176–180.
  • Borkowski, R., Du, L., Minna, J. D., Gazdar, A. F., & Pertsemilidis, A. (2011). A miRNA inhibitor screen for synthetic lethal interactions in KRAS-driven NSCLC. Cancer Research, 71(8 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/71/8_Supplement/3958
  • Du, L., Subauste, M. C., Baker, M., DeSevo, C. F., & Pertsemilidis, A. (2011). miR-337-3p and its targets STAT3 and RAP1A modulate paclitaxel sensitivity in non-small cell lung cancers (NSCLCs). Cancer Research, 71(8 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/71/8_Supplement/4709
2010
  • Du, L., Schageman, JJ., Irnov, Girard, L., Hammond, SM., Minna, JD., … Pertsemlidis, A. (2010). microRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. J Exp Clin Cancer Res, 29, 75.
  • Subauste, MC., Sansom, OJ., Porecha, N., Raich, N., Du, L., & Maher, JF. (2010). Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. Mol Carcinog, 49(2), 105–113.
  • Du, L., & Pertsemlidis, A. (2010). microRNAs and lung cancer: tumors and 22-mers. Cancer Metastasis Rev, 29(1), 109–122.
2009
  • Subauste, MC., Ventura-Holman, T., Du, L., Subauste, JS., Chan, SL., Yu, VC., & Maher, JF. (2009). RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. Cancer Biol Ther, 8(23), 2297–2305.
  • Gibbons, DL., Lin, W., Creighton, CJ., Rizvi, ZH., Gregory, PA., Goodall, GJ., … Kurie, JM. (2009). Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev, 23(18), 2140–2151.
  • Du, L., Schageman, JJ., Subauste, MC., Saber, B., Hammond, SM., Prudkin, L., … Pertsemlidis, A. (2009). miR-93, miR-98 and miR-197 regulate expression of tumor suppressor gene. FUS1. Mol Cancer Res, 7(8), 1234–1243.
  • Du, L., Saber, B. C., Rachel, G., Gazdar, A. F., White, M., Minna, J. D., & Pertsemilidis, A. (2009). Abstract# 1381: miR-337 modulates sensitivity to paclitaxel in non_small cell lung cancer. Cancer Research, 69(9 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/69/9_Supplement/1381.short
2008
  • Calderon, L. E., Du, L., Nikolic, D., & Post, S. R. (2008). Regulation of class a scavenger receptor expression by M-CSF: The” Ups” and” Downs” of SR-A. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(6), E121.
  • Du, L., Greer, R., Schageman, J., Gazdar, A., White, M., Minna, J. D., & Pertsemilidis, A. (2008). microRNA regulation of chemoresistance in non-small cell lung cancer (NSCLC). Cancer Research, 68(9 Supplement). Retrieved from https://cancerres.aacrjournals.org/content/68/9_Supplement/5042.short
2005
  • Post, S. R., Du, L., & Nikolic, D. (2005). M-csf Stimulates SR-A Expression in Macrophages via the Ptx-Sensitive Activation of P38 Kinase. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(5), 114.
2004
  • Du, L., & Post, S. (2004). Macrophage-colony stimulating factor differentially regulates low-density lipoprotein and transferrin receptor. J Lipid Res, 45(9), 1733–1740.
  • Du, L. (2004). Regulation of LDL receptor-mediated endocytosis by microphage-colony stimulating factor. Lexington, KY, United States. Retrieved from https://search.proquest.com/openview/10d54f8a418acc090fb047e8fb7fc8a8/1?pq-origsite=gscholar&cbl=18750&diss=y
2001
  • Du, L., & Post, S. R. (2001). Microphage-colony stimulating factor differentially regulates transferrin and LDL receptor-mediated endocytosis. Circulation, 71(17), 233–233.